Chronic multifocal paracoccidioidomycosis with perioral and laryngeal involvement in an immunocompetent patient: case report

Main Article Content

Wilson Galvis Franco
Camilo Ruiz Mejía
Diana Pérez Villegas

Abstract

Introduction: Paracoccidioidomycosis is a mycosis endemic in tropical areas of South America and Central America. 50% of patients have mucous membrane involvement and the laryngeal mucosa is affected in 22-43% of cases. Case report: We present an illustrative case of a patient with Paracoccidioidomycosis with involvement of the oral and laryngeal mucosa with a clinical course suggestive of disseminated tuberculosis. Discussion: Mucosal involvement occurs in half of the patients with Paracoccidioidomycosis, while laryngeal involvement occurs in 22- 43% of patients. In most cases, laryngeal lesions are observed as granulomatous masses with a hemorrhagic surface and are associated with dysphonia, making them difficult to differentiate from laryngeal tuberculosis. Conclusion: Laryngeal involvement in patients with Paracoccidioidomycosis is frequent and has a clinical course similar to that of tuberculosis, implying a diagnostic challenge.

Downloads

Download data is not yet available.

Article Details

How to Cite
1.
Galvis Franco W, Ruiz Mejía C, Pérez Villegas D. Chronic multifocal paracoccidioidomycosis with perioral and laryngeal involvement in an immunocompetent patient: case report. Acta otorrinolaringol cir cabeza cuello [Internet]. 2024Feb.7 [cited 2024May13];51(4):310 - 315. Available from: https://www.revista.acorl.org.co/index.php/acorl/article/view/698
Section
Reportes de Casos

References

Alvares BA, Gracia CAL, Marques MEA, Marques SA. Paracoccidioidomycosis: an uncommon clinical presentation. An Bras Dermatol. 2020;95(6):740-42. doi: 10.1016/j. abd.2020.06.001

Mariaca Flórez CJ, Cardona Castro N. Paracoccidioidomicosis. Med UPB. 2015;34(2):126-37. doi: 10.18566/ medupb.v34n2. a05

Benard G. Pathogenesis and Classification of Paracocidioidomycosis: New Insights From Old Good Stuff. Open Forum Infect Dis. 2020;16;8(3):ofaa624. doi: 10.1093/ ofid/ofaa624

Costa AFP, Dos Santos VM, Leite MR, de Farias Filho FT. A Brazilian male with typical oral and pulmonary paracoccidioidomycosis. Med J Islam Repub Iran. 2019;33:145. doi: 10.34171/mjiri.33.145

Arenas CM, Sánchez Tenorio L, Ballén Suárez J, Rodríguez Toro G. Síndrome verrugoso tropical. Piel (Barc). 2016;31(10):699- 705. doi: 10.1016/j.piel.2016.02.011

Tirado-Sánchez A, González GM, Bonifaz A. Endemic mycoses: epidemiology and diagnostic strategies. Expert Rev Anti Infect Ther. 2020;18(11):1105-17. doi: 10.1080/14787210.2020.1792774

Queiroz-Telles F, Fahal AH, Falci DR, Caceres DH, Chiller T, Pasqualotto AC. Neglected endemic mycoses. Lancet Infect Dis. 2017;17(11):e367-77. doi: 10.1016/S1473-3099(17)303067

Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, et al. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis. 2021;21(12):e364-74. doi: 10.1016/S1473-3099(21)00191-2

Pissurno NSCA, Esteves LDM, Benedito JM, Giglio VP, de Carvalho LR, Mendes RP, et al. Impact of laryngeal sequelae on voice- and swallowing-related outcomes in paracoccidioidomycosis. J Venom Anim Toxins Incl Trop Dis. 2020;26:e20200008. doi: 10.1590/1678-9199-JVATITD-2020-0008

Weber SA, Brasolotto A, Rodrigues L, Marcondes-Machado J, Padovani CR, Carvalho LR, et al. Dysphonia and laryngeal sequelae in paracoccidioidomycosis patients: a morphological and phoniatric study. Med Mycol. 2006;44(3):219-25. doi: 10.1080/13693780500340320

Sant’Anna GD, Mauri M, Arrarte JL, Camargo H Jr. Laryngeal manifestations of paracoccidioidomycosis (South American blastomycosis). Arch Otolaryngol Head Neck Surg. 1999; 125(12):1375-78.

Trindade AH, Meira HC, Pereira IF, de Lacerda JCT, de Mesquita RA, Santos VR. Oral paracoccidioidomycosis: Retrospective analysis of 55 Brazilian patients. Mycoses. 2017;60(8):521-25. doi: 10.1111/myc.12622

de Arruda JAA, Schuch LF, Abreu LG, Silva LVO, Mosconi C, Monteiro JLGC, et al. A multicentre study of oral paracoccidioidomycosis: Analysis of 320 cases and literature review. Oral Dis. 2018;24(8):1492-502. doi: 10.1111/odi.12925

Souza RL, Bonan PR, Pinto MB, Prado JD, de Castro JF, Carvalho EA, et al. Oral paracoccidioidomycosis in a nonendemic region from Brazil: A short case series. J Clin Exp Dent. 2019;11(10):e865-70. doi: 10.4317/jced.56199

Amorim Pellicioli AC, Neves-Silva R, Santos-Silva AR, Vargas PA, Lopes MA. Synchronous oral paracoccidioidomycosis and pulmonary tuberculosis in an immunocompetent patient. Mycopathologia. 2015;179(5-6):459-64. doi: 10.1007/s11046- 015-9868-3

Torres-Pereira C, Giovanini AF, Stramandinoli RT, Amenabar JM, Piazzetta CM. Oral paracoccidioidomycosis and pulmonary tuberculosis co-infection: relevance of oral biopsy in establishing the diagnosis and therapeutic approach. Int J Infect Dis. 2009;13(1):114-6. doi: 10.1016/j.ijid.2008.04.008